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The least-squares mean percentage change in body weight from baseline was -7.2% in the 1 mg group, -12.9% in the 4 mg group (starting at 2 mg), -17.1% in the combined 4 mg groups, -17.5% in the combined 8 mg groups, and -17.5% in the 12 mg group, compared with -1.6% in the placebo group

Gabapentin impacts mood and cognition by controlling the release of gamma-aminobutyric acid (GABA) in the brain, which results in calming effects

Changes in blood glucose levels, weight, or general wellbeing should be communicated to your healthcare team so that your overall management plan can be reviewed and adjusted as needed

Both therapies converge on the same cellular signaling pathways, and their combined effect may be greater than the sum of their parts

One option could be lower gallbladder motility, which enhances biliary sludge formation and bile stones